[PDF] Long-term Chikungunya Sequelae in Curaçao: Burden, Determinants, and a Novel Classification Tool | Semantic Scholar (2024)

Patients are both physically and psychologically affected by rheumatic and non-rheumatic symptoms of long-term chikungunya disease and highly affected patients are recommended to be treated in a multidisciplinary setting to improve physical and psychological functioning, and QoL.

Rheumatic and non-rheumatic symptoms, and QoL impairment may persist, 60months following infection with the Asian CHIKV genotype, similar to the IOL genotype disease sequelae.

Knee joint pain remarks a significant dilemma post-CHIKV, and these remarks were linked with the risk of subsequently creating chronic sequelae.

Increased duration of acute symptoms, in particular acute joint pain, was strongly correlated with the risk of persistent arthralgia, thus effective clinical management of acute CHikV disease could reduce burden of chronic CHIKV.

Persistent impact on morbidity, health outcomes, psychological, and economic aspects further underline the crucial role of community-based medicine and the necessity of an evidence-based multidisciplinary approach toward chronic stage CHIK identification, management, and follow-up in this particular world region.

It is confirmed that musculoskeletal symptoms are not the only determinants of quality of life in chronic chikungunya disease, and follow-up of patients should include assessment and management of fatigue, poor sleep quality, and anxiodepressive syndromes.

An in-depth understanding of acute and long-term HRQoL impact of chikungunya can better inform health promotion policies and interventions and promote healthy and efficient coping strategies in affected individuals.

Interventions such as cognitive–behavioural therapy and mindfulness exercises may be effective in strengthening or regain affected individual’s sense of competence and control by fostering adaptive coping skills and resilience when rheumatic symptoms persist following chikungunya virus infection.

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Initial CHIKV severity predicted recovery, with higher severity associated with arthritis and lower severity with arthralgia, and specific markers of post-CHIKV arthritis were identified.

More than one year following the acute phase of infection, CHIK+ subjects reported more disabilities than those who were CHIK–, which have no significant influence on medical consumption and the impact on quality of life is moderate.

It is demonstrated that chronic arthralgia is a frequent complication of acute Chikungunya disease and suggests that it results from a local rather than systemic inflammation.

Medical follow-up with special attention to comorbidity providing information on possible chronic symptoms and giving support for potential depression and anxiety are recommended.

By identifying the prognostic value of the humoral immune response of the host, this work suggest a significant contribution of the adaptive immune response to the physiopathology of CHIK-R and should help to reconsider the paradigm of this chronic infection primarily shifted towards the involvement of the innate immune response.

It is suggested that long-term CHIKV rheumatic manifestations seem to be a frequent underlying post-epidemic condition and may be particularly useful in the development of future prevention and care strategies for this emerging virus infection.

Persistence of pain noted in post-CKG disease resulted in significantly deteriorated functional status of those affected, and the effect of chronic rheumatic and musculoskeletal symptoms on the functional status was found to be significant.

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